Essentiality of n-6 fatty acids

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Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer.

BACKGROUND Laboratory studies have shown that n-3 fatty acids inhibit and n-6 fatty acids stimulate prostate tumor growth, but whether the dietary intake of these fatty acids affects prostate cancer risk in humans remains unclear. OBJECTIVE We prospectively evaluated the association between intakes of alpha-linolenic (ALA; 18:3n-3), eicosapentaenoic (EPA; 20:5n-3), docosahexaenoic (DHA; 22:6n...

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Workshop on the essentiality of and recommended dietary intakes for omega-6 and omega-3 Fatty acids.

The Workshop on the Essentiality of and Recommended Dietary Intakes (RDIs) for Omega-6 and Omega-3 Fatty Acids was held at The Cloisters, National Institutes of Health (NIH) in Bethesda, Maryland, USA, April 7–9, 1999. The workshop was sponsored by the National Institute on Alcohol Abuse and Alcoholism-NIH, the Office of Dietary Supplements-NIH, The Center for Genetics, Nutrition and Health, an...

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Metabolism of n-3/n-6 fatty acids in blood and vascular cells.

Except in adipose tissue. polyunsaturated fatty acids (PUFA j of mammalian cells arc mainly located in membrane phospholipids where they have a structural role, and some of them serve as precursors o f oxygenated derivatives which may function as lipid mediators. Among these PUFA, arachidonic acid (20:4.n 6 ) , and to a lesser extent. linoleic acid ( 1 8:2, t i 6) are generally found in the hig...

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Effect of dietary n-3 and n-6 fatty acids on tobramycin induced nephrotoxicity.

Post fish oil(n-3 fatty acids) treatment (5mg/kg/day for 12 days) was effective in bringing the reversal of tobramycin (160mg/kg/day,ip for 12 days) induced nephrotoxicity in albino rats as was evident by normal urea, creatinine, cholesterol and inorganic phosphate levels in the serum of the treatment group compared with group receiving tobramycin only. The return of normal levels of alkaline a...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2019

ISSN: 0021-9258

DOI: 10.1074/jbc.l119.008356